flurouracil 50

Action interferes with the synthesis of DNA and to a lesser extent that of RNA by blocking the methylation reaction of deoxyuridylic acid to thymidylic acid. This results in unbalanced growth and that of the cells. The effect of 5 FU is more on rapidly growing cells which take up this drug at a more rapid rate.
Indication as an adjuvant to radiotherapy, surgery and in combination with other drugs : Maligant neoplasms of breast, G.I.Tract and carcinoma of pancreas. Carcinoma of urinary bladder, hepatoma, carcinoma of colon, topical treatment of premalignant keratosis of skin and multiple superficial basal cell carcinomas.
Dosage:edults : 12mg / kg body weight once daily for 4 successive days I.V.Max. daily Dosage:800 mg If no toxicity give 6mg / kg on days 6,8,10,12, discontinue day 12. Maintain Dosage: 10-15mg / kg per week, Max Dose 1g/ week.