Doxorubicin 50

Uses Doxorubicin is a cytotoxic anthracycline antibiotic. The cytotoxic action results from its binding to DNA and inhibition of nucleic acid symthesis. Doxorubicin has been shown to produce regression in a variety of disseminated malignancies.
Indications:GIT carcinoma. Acute myeloblastic leukaemia, bronchogenic, breast and ovarian carcinoma, soft tissue and bone sarcomas, malignant lymphoma. Primary management of nonmetastatic bladder carcinoma (intravesical administration). Wilm's tumor. Neuroblastoma.
Adverse Effects, and Precautions: Doxorubicin and other anthracyclines cause pronounced bone-marrow depression. White cell count reaches a nadir 10 to 15 days after a Dose and usually recovers by about 21 days. 2- cardiac toxicity, both as an acute, usually transient disturbance.of cardiac function marked by ECG abnormalities and, sometimes, arrhythmias; and as a delayed, sometimes fatal, irreversible congestive heart failure. . . . . . etc Dosage:Adults : I.V. : 60 75mg / m2 single dose every 21 days or 30 mg / m2 daily every 3 days. Repeat after 4 weeks. Maximum Dose 550 mg / m2.