Rifampicin 300

Interactions: accelerates the metabolism of some drugs by inducing microsomal liver enzymes and possibly by interfering with hepatic uptake so these drugs require an increase in Dosage to maintain effectiveness, women taking oral contraceptives additional Precautions or change to a non-hormonal form of contraception
Precautions:care should be taken in alcoholic patients or those with pre-existing liver disease who require regular monitoring during therapy., contra-indicated in patients with jaundice. A self-limiting hyperbilirubinaemia may occur the first 2 or 3 weeks of ttt.
Dosage.ttt of the sputum positive T.B. the following suggested method can be used : ( the total duration of therapy 9 monthes ) : 1 ( Rifamycin 450 mg+isoniazide300 mg+ethambutol 1200 mg ) for 2 months 2 ( Rifamycin 450mg+isoniazide 300mg) for 7 months.